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KMID : 1134820200490070754
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Journal of the Korean Society of Food Science and Nutrition
2020 Volume.49 No. 7 p.754 ~ p.758
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Effect of Hot Water Extract of Salvia plebeia R. on the Production of Splenocyte Cytokines in Mouse
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Shin Jin-Seop
Park Jeong-Jin
Jun Woo-Jin
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Abstract
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This study examined the antioxidant and immuno-enhancement effects of Salvia plebeia R. For the antioxidant activities, the total polyphenol and, flavonoid contents were 99.10±2.53 mg gallic acid equivalent/g and, 48.71±1.06 mg catechin equivalent/g, respectively. 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) and 1,1-diphenyl-2-picrylhydrazyl radical scavenging activities increased in a dose-dependent manner. The oxygen radical absorbance capacity was 109±1.78 nm Trolox equivalent/mL. The levels of IL-2 and IL-12 cytokine production on C57BL/6 mice splenocytes (the FIE-SP group, 150 μg/mL) were significantly higher than the CON group. These results suggest that S. plebeia R. might increase the antioxidant activity, and immune-enhancement effect.
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KEYWORD
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Salvia plebeia R., antioxidant activities, splenocyte, imuuno-enhancement, cytokine
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